May 17 2018Alexo Therapeutics, a clinical-stage immuno-oncology company developing therapies to block the CD47 checkpoint mechanism, today announced it has initiated ALX148 combination dosing with targeted antibody therapies in its Phase 1 clinical program in patients with advanced solid tumors and lymphoma. The Company will present updated data on ALX148 at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL.Related StoriesStability Testing of Therapeutic Proteins using DLS and Machine LearningAbcam Acquire Off-The-Shelf Diploid Library of Over 2,800 Knockout Cell LinesUsing Light Scattering to Characterize Protein-Nucleic Acid Interactions”The initiation of ALX148 combination cohorts marks the next important milestone in Alexo’s development,” said Sophia Randolph M.D., Ph.D., Chief Medical Officer of Alexo Therapeutics. “ALX148 is designed to enhance the efficacy of antibody-based therapies, while avoiding the dose-limiting toxicities that have been seen with other CD47-targeted approaches in the clinic. ALX148 is generally well tolerated in patients with advanced tumors and exhibits favorable pharmacokinetics and CD47 target occupancy at doses evaluated. No maximum tolerated dose of ALX148 was reached. With broad therapeutic potential across many types of cancer, we are eager to now be evaluating ALX148 in combination with select anti-cancer therapeutic antibodies.”The ALX148 Phase 1 clinical trial is a two-part study that evaluates the safety, pharmacokinetics, and pharmacodynamics of ALX148. Enrollment to the single-agent dose escalation phase is complete and the combination therapy portion in which ALX148 is administered with approved anti-cancer antibodies is ongoing. Clinical data will be presented at the ASCO 2018 Annual Meeting. Source:http://alexotherapeutics.com/pr/2018/051718.html
"Alexo Therapeutics marks next significant milestone by initiating ALX148 combination cohorts"